Endophilin I Rabbit Polyclonal Antibody

Domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface., function:Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature., miscellaneous:HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation., similarity:Belongs to the endophilin family., similarity:Contains 1 BAR domain., similarity:Contains 1 SH3 domain., subcellular location:Concentrated in presynaptic nerve terminals in neurons., subunit:Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity) . Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP., tissue specificity:Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum., domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface., function:Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature., miscellaneous:HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N-terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation., similarity:Belongs to the endophilin family., similarity:Contains 1 BAR domain., similarity:Contains 1 SH3 domain., subcellular location:Concentrated in presynaptic nerve terminals in neurons., subunit:Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity) . Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP., tissue specificity:Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.