Cleaved-GGT4 HC (T472) Rabbit Polyclonal Antibody

This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008], catalytic activity: (5-L-glutamyl) -peptide + an amino acid = peptide + 5-L-glutamyl amino acid., function:Cleaves glutathione conjugates., pathway:Sulfur metabolism; glutathione metabolism., similarity:Belongs to the gamma-glutamyltransferase family., subunit:Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity) . Isoform 3 interacts with FAM57A., tissue specificity:Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.

GGT7; GGTL3; GGTL5; Gamma-glutamyltransferase 7; GGT 7; Gamma-glutamyltransferase-like 3; Gamma-glutamyltransferase-like 5; Gamma-glutamyltranspeptidase 7; Glutathione hydrolase 7