Axl Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6) . This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013], catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia., function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 2 fibronectin type-III domains., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., subunit:Heterodimer and heterotetramer with GAS6., tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.