NAV3 Rabbit Polyclonal Antibody

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008], developmental stage:Expressed in fetal brain., disease:Defects in NAV3 may be a cause of mycosis fungoides [MIM:254400]; a malignant T-cell lymphoma of the skin., disease:Defects in NAV3 may be a cause of Sezary syndrome, a malignant T-cell lymphoma of the skin., function:May regulate IL2 production by T-cells. May be involved in neuron regeneration., similarity:Belongs to the Nav/unc-53 family., similarity:Contains 1 CH (calponin-homology) domain., tissue specificity:Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level) . Down-regulated in primary neuroblastoma.