PTP22 Rabbit Polyclonal Antibody

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009], catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate., function:Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases., similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily., similarity:Contains 1 tyrosine-protein phosphatase domain., tissue specificity:Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.

PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP