WNK2 Rabbit Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], catalytic activity:ATP + a protein = ADP + a phosphoprotein., caution:Cys-224 is present instead of the conserved Lys which is expected to be an active site residue. Lys-207 appears to fulfill the required catalytic function., cofactor:Magnesium., enzyme regulation:Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily., similarity:Contains 1 protein kinase domain., tissue specificity:Predominantly expressed in heart, brain and colon.
Gene Name
WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13
Gene ID
65268
Swiss Prot
Q9Y3S1
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF
Purification
Affinity purification
Dilution
IHC 1:50-1:300, ICC/IF 1:50-1:200
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
252kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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