TRIO Rabbit Polyclonal Antibody

This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015], catalytic activity:ATP + a protein = ADP + a phosphoprotein., domain:The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers., function:Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth., PTM:Phosphorylated on serine residue (s) ., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family., similarity:Contains 1 CRAL-TRIO domain., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 protein kinase domain., similarity:Contains 2 DH (DBL-homology) domains., similarity:Contains 2 PH domains., similarity:Contains 2 SH3 domains., similarity:Contains 4 spectrin repeats., subunit:Interacts to form a complex with leukocyte antigen related protein., tissue specificity:Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.