LRBA Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS) . The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012], caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited., induction:By lipopolysaccharide (LPS) ., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 BEACH domain., similarity:Contains 6 WD repeats.