CD109 Rabbit Polyclonal Antibody

This gene encodes a glycosyl phosphatidylinositol (GPI) -linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014], function:Modulates negatively TGFB1 signaling in keratinocytes., polymorphism:The Gov (b) variant in position 703 defines the Gov alloantigenic determinants., PTM:2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form., PTM:N-glycosylated., similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family., subunit:Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner., tissue specificity:Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34 (+) acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.

CD109 antigen (150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CD antigen CD109)