CD242 Rabbit Polyclonal Antibody

This gene encodes the Landsteiner-Wiener (LW) blood group antigen (s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW (A) /LW (B) blood group antigens is a single aa variation at position 100; Gln-100=LW (A) and Arg-100=LW (B) . Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008], function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins., online information:Blood group antigen gene mutation database, polymorphism:Responsible for the Landsteiner-Wiener blood group system. The molecular basis of the LW (A) =LW5/LW (B) =LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW (A) and Arg-100 to LW (B) ., PTM:N- and O-glycosylated., similarity:Belongs to the immunoglobulin superfamily. ICAM family., similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains., tissue specificity:Erythrocytes.