Connexin 46 Rabbit Polyclonal Antibody

The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3) . [provided by RefSeq, Jan 2010], disease:Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. CZP3 is a form of autosomal dominant congenital cataract., function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., similarity:Belongs to the connexin family. Alpha-type (group II) subfamily., subunit:A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.