Cdc25C (phospho Ser198) Rabbit Polyclonal Antibody
Product Specifications
Background
Cell division cycle 25C (CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015], catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate., developmental stage:Expressed predominantly in G2 phase., function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity., PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase., similarity:Belongs to the MPI phosphatase family., similarity:Contains 1 rhodanese domain., subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.
Product Name Alternative
CDC25C; M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C
Gene Name
CDC25C
Gene ID
995
Swiss Prot
P30307
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Cell_Cycle_G1S; Cell_Cycle_G2M_DNA; Oocyte meiosis; Progesterone-mediated oocyte maturation
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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