SerpinA6 Rabbit Polyclonal Antibody

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008], disease:Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue., function:Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species., online information:Transcortin entry, PTM:Glycosylation in position Asn-260 is needed for steroid binding., PTM:N-glycosylated; binds 5 oligosaccharide chains., similarity:Belongs to the serpin family., tissue specificity:Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.