Adducin α (phospho Thr445) Rabbit Polyclonal Antibody

Adducin 1 (ADD1) Homo sapiens Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma) . Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca (2+) /calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008], alternative products:Additional isoforms seem to exist, domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region., function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin., PTM:The N-terminus is blocked., similarity:Belongs to the aldolase class II family. Adducin subfamily., subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1., tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.