USP48 Rabbit Polyclonal Antibody

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., caution:Was named USP31 by some authors (PubMed:15354349 and PubMed:17081983) ., function:Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the peptidase C19 family., similarity:Contains 1 ubiquitin-like domain., similarity:Contains 3 DUSP domains., subunit:Interacts with TRAF2 and RELA., tissue specificity:Widely expressed.

USP48; USP31; Ubiquitin carboxyl-terminal hydrolase 48; Deubiquitinating enzyme 48; Ubiquitin thioesterase 48; Ubiquitin-specific-processing protease 48