AGS3 Rabbit Polyclonal Antibody

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], domain:The GoLoco domains mediate interaction with G (i/o) alpha (By similarity) . The GoLoco domains are essential for the GDI activity toward G (i/o) alpha., function:Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G (i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction., PTM:Phosphorylation regulates interaction with G (i/o) alpha., similarity:Belongs to the GPSM family., similarity:Contains 4 GoLoco domains., similarity:Contains 9 TPR repeats., subunit:Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity) . Interacts with INSC/inscuteable and FRMPD1., tissue specificity:Expressed in intestinal cells.