BID (phospho Ser78) Rabbit Polyclonal Antibody

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8) ; CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008], domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family., function:The major proteolytic product p15 BID allows the release of cytochrome c (By similarity) . Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products., subcellular location:A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively., subcellular location:Associated with the mitochondrial membrane., subcellular location:Translocates to mitochondria as an integral membrane protein., subcellular location:When uncleaved, it is predominantly cytoplasmic., subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2., tissue specificity:Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level) . Isoform 3 is expressed in lung, pancreas and spleen (at protein level) . Isoform 4 is expressed in lung and pancreas (at protein level) .

P53; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; Natural killer cell mediated cytotoxicity; Alzheimer's disease; Amyotrophic lateral sclerosis (ALS) ; Pathways in cancer; Viral myocarditis