MLK1/2 Rabbit Polyclonal Antibody
Product Specifications
Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation., function:Activates the JUN N-terminal pathway., PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH3 domain., subunit:Homodimer., tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin., catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation., function:Activates the JUN N-terminal pathway., PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH3 domain., subunit:Homodimer., tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Product Name Alternative
MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST
Gene Name
MAP3K9/MAP3K10
Gene ID
4293/4294
Swiss Prot
P80192/Q02779
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Regulation of Actin Dynamics; SAPK_JNK; Stem cell pathway; B_Cell_Antigen
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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