MEK Kinase-6 Rabbit Polyclonal Antibody

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation., function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 protein kinase domain., subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.

SAPK_JNK; Regulation of Actin Dynamics; Cell Growth; Stem cell pathway; Cell_Cycle_G1S; Cell_Cycle_G2M_DNA; MAPK_ERK_Growth; MAPK_G_Protein; B Cell Receptor