ADAMTS-7 Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016], cofactor:Binds 1 zinc ion per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix., function:Metalloprotease that may play a role in the degradation of COMP., induction:Up-regulated in articular cartilage and synovium from arthritis patients., PTM:May be cleaved by a furin endopeptidase (By similarity) . The precursor is sequentially processed., PTM:N-glycosylated., PTM:O-glycosylated proteoglycan. Contains chondroitin sulfate., similarity:Contains 1 disintegrin domain., similarity:Contains 1 peptidase M12B domain., similarity:Contains 1 PLAC domain., similarity:Contains 8 TSP type-1 domains., subcellular location:Also found associated with the external cell surface., subunit:Interacts with COMP., tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.