DNA pol ε A Rabbit Polyclonal Antibody
Product Specifications
Background
DNA polymerase epsilon, catalytic subunit (POLE) Homo sapiens This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013], catalytic activity:Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1) ., domain:The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme., function:Participates in DNA repair and in chromosomal DNA replication., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the DNA polymerase type-B family., subunit:Consists of two subunits (258 kDa and 55 kDa) . Interacts with RAD17 and TOPBP1.
Product Name Alternative
POLE; POLE1; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A
Gene Name
POLE
Gene ID
5426
Swiss Prot
Q07864
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Purine metabolism; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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