UBE2G1 Rabbit Polyclonal Antibody

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008], catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine., function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins., pathway:Protein modification; protein ubiquitination., similarity:Belongs to the ubiquitin-conjugating enzyme family., tissue specificity:Widely expressed, mainly in skeletal muscle.