Rag B Rabbit Polyclonal Antibody

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3) . Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008], function:Involved in the RCC1/Ran-GTPase pathway. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity., similarity:Belongs to the GTR/RAG GTP-binding protein family., subunit:The short isoform binds GTP (By similarity) . Interacts with RRAGC and RRAGD.