PIG-H Rabbit Polyclonal Antibody

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) -anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008], catalytic activity:UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6- (N-acetyl-alpha-D-glucosaminyl) -1-phosphatidyl-1D-myo-inositol., function:Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., online information:Phosphatidylinositol N-acetylglucosaminyltransferase subunit H, pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis., similarity:Belongs to the PIGH family., subunit:Associates with PIGA, PIGC, PIGP, PIGQ and DPM2. The latter is not essential for activity.