DNA pol ε 4 Rabbit Polyclonal Antibody
Product Specifications
Background
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004], catalytic activity:Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1) ., function:May play a role in allowing polymerase epsilon to carry out its replication and/or repair function., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., subunit:Consists of four subunits: POLE1, POLE2, POLE3 and POLE4. Interacts with POLE3. When bound to POLE3, it can associate with polymerase epsilon p261 and p59 and form a complex.
Product Name Alternative
POLE4; DNA polymerase epsilon subunit 4; DNA polymerase II subunit 4; DNA polymerase epsilon subunit p12
Gene Name
POLE4
Gene ID
56655
Swiss Prot
Q9NR33
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Purine metabolism; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
12kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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