BinCARD Rabbit Polyclonal Antibody

Function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner., PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 CARD domain., subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol., subunit:Associates with BCL10 by CARD-CARD interaction., tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level) . Expressed in thymus and brain., function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner., PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 CARD domain., subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol., subunit:Associates with BCL10 by CARD-CARD interaction., tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level) . Expressed in thymus and brain.