ADAMTS-12 Rabbit Polyclonal Antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008], cofactor:Binds 1 zinc ion per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix., PTM:Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains., PTM:The precursor is cleaved by a furin endopeptidase., similarity:Contains 1 disintegrin domain., similarity:Contains 1 peptidase M12B domain., similarity:Contains 1 PLAC domain., similarity:Contains 8 TSP type-1 domains., tissue specificity:Expressed exclusively in fetal lung. Is widely expressed in gastric carcinomas and in cancer cells of diverse origin.