BS69 Rabbit Polyclonal Antibody

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008], function:Binds to the transactivation domain of the adenovirus type 5 E1A 32 kDa protein (289R) and inhibits its transactivating activity. May act as tumor suppressor through suppression of adenovirus replication., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 bromo domain., similarity:Contains 1 MYND-type zinc finger., similarity:Contains 1 PHD-type zinc finger., similarity:Contains 1 PWWP domain.