PI 3-kinase p101 Rabbit Polyclonal Antibody

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011], domain:The heterodimerization region allows the binding to the catalytic subunit., enzyme regulation:Greatly activated by G gamma proteins., function:Regulatory subunit of the PI3K gamma complex., subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins., tissue specificity:Highly expressed in leukocytes, followed by spleen, lymph node, thymus ans bone marrow.

PIK3R5; Phosphoinositide 3-kinase regulatory subunit 5; PI3-kinase regulatory subunit 5; PI3-kinase p101 subunit; Phosphatidylinositol 4; 5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-

ErbB_HER; Chemokine; Phosphatidylinositol signaling system; mTOR; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; VEGF; Focal adhesion; Toll_Like; Jak_STAT; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Fc epsilon RI; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin; Regulates Actin and Cytoskeleton; Insulin_Receptor; Progesterone-mediated oocyte maturation; Type II diabetes mellitus; Aldosterone-regulated sodium reabsorption; Pathways in cancer; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer