ETO-2 Rabbit Polyclonal Antibody

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (16;21) (q24; q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010], disease:A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t (16;21) (q24; q22) that forms a RUNX1-CBFA2T3 fusion protein., function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486) ., induction:Down-regulated by all-trans retinoic acid., similarity:Belongs to the CBFA2T family., similarity:Contains 1 MYND-type zinc finger., similarity:Contains 1 TAFH (NHR1) domain., subcellular location:The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm., subunit:Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity) . Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to Hoogeveen et al (PubMed:12242670) may not interact with HDAC6. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A., tissue specificity:Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level) .

CBFA2T3; MTG16; MTGR2; ZMYND4; Protein CBFA2T3; MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; hMTG16; Zinc finger MYND domain-containing protein 4