KLF8 Rabbit Polyclonal Antibody

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009], function:Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G (1) phase as a downstream target of focal adhesion kinase (FAK) ., PTM:Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G (1) phase. Has no effect on subcellular location., similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family., similarity:Contains 3 C2H2-type zinc fingers., subunit:Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8., tissue specificity:Ubiquitous.