IL-1RI (phospho Tyr496) Rabbit Polyclonal Antibody

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013], function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA) . Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2., similarity:Belongs to the interleukin-1 receptor family., similarity:Contains 1 TIR domain., similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains., subunit:Binds IL1RAP.

IL1R1; IL1R; IL1RA; IL1RT1; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD antigen CD121a

MAPK_ERK_Growth; MAPK_G_Protein; Cytokine-cytokine receptor interaction; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; Hematopoietic cell lineage