Calgizzarin Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008], function:Facilitates the differentiation and the cornification of keratinocytes., miscellaneous:Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins., PTM:Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation., similarity:Belongs to the S-100 family., similarity:Contains 2 EF-hand domains., subunit:Homodimer; disulfide-linked.