DAPK1 (phospho Ser308) Rabbit Polyclonal Antibody
Product Specifications
Background
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013], catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Negatively regulated by autophosphorylation on Ser-308., function:Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis., induction:Up-regulated following treatment with interferon-gamma., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily., similarity:Contains 1 death domain., similarity:Contains 1 protein kinase domain., similarity:Contains 10 ANK repeats., subcellular location:Colocalizes with the actin filament system.
Product Name Alternative
DAPK1; DAPK; Death-associated protein kinase 1; DAP kinase 1
Gene Name
DAPK1
Gene ID
1612
Swiss Prot
P53355
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Field of Research
Pathways in cancer; Bladder cancer
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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