CARD 14 Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012], caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART., function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10., similarity:Contains 1 CARD domain., similarity:Contains 1 guanylate kinase-like domain., similarity:Contains 1 PDZ (DHR) domain., subunit:CARD14 and BCL10 bind to each other by CARD-CARD interaction., tissue specificity:Expressed in placenta. Also detected in HeLa S3 cells, but not in the other cancer cell lines tested.
Product Name Alternative
CARD14; CARMA2; Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2
Gene Name
CARD14
Gene ID
79092
Swiss Prot
Q9BXL6
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF, ELISA
Purification
Affinity purification
Dilution
IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
110kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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