DGK-κ Rabbit Polyclonal Antibody

The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011], catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate., enzyme regulation:Inhibited in response to H (2) O (2) ., function:Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) ., PTM:Phosphorylated at Tyr-78 by some member of the SRC family in response to H (2) O (2) ., similarity:Belongs to the eukaryotic diacylglycerol kinase family., similarity:Contains 1 DAGKc domain., similarity:Contains 1 PH domain., similarity:Contains 2 phorbol-ester/DAG-type zinc fingers., subunit:Does not form homooligomers., tissue specificity:Expressed in testis, and to a lesser extent in placenta.