S-100P Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008], miscellaneous:This protein binds two calcium ions., similarity:Belongs to the S-100 family., similarity:Contains 2 EF-hand domains., subcellular location:Colocalizes with S100PBP in the nucleus., subunit:Homodimer. Interacts with S100PBP and S100Z., tissue specificity:Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.