CD269 Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008], disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL) . Translocation t (4;16) (q26; p13) with IL2., function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK., similarity:Contains 1 TNFR-Cys repeat., subcellular location:Perinuclear Golgi-like structures., subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6., tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.