ME2 Rabbit Polyclonal Antibody

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009], catalytic activity: (S) -malate + NAD (+) = pyruvate + CO (2) + NADH., cofactor:Divalent metal cations. Prefers magnesium or manganese., enzyme regulation:Subject to allosteric activation by fumarate., miscellaneous:This isoenzyme can also use NADP (+) but is more effective with NAD (+) ., similarity:Belongs to the malic enzymes family., subunit:Homotetramer.