COL19A1 Rabbit Polyclonal Antibody

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices) . Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008], domain:The numerous interruptions in the triple helix may make this molecule either elastic or flexible., function:May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle., PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains., similarity:Belongs to the fibril-associated collagens with interrupted helices (FACIT) family., similarity:Contains 1 TSP N-terminal (TSPN) domain., subunit:Oligomer; disulfide-linked., tissue specificity:Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.