Centrobin Rabbit Polyclonal Antibody

This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011], developmental stage:Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases., function:Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Wrong choice of frame., subcellular location:Centriole-associated, asymmetrically localizes to the daughter centriole., subunit:Interacts with LYST., tissue specificity:Widely expressed (at protein level) . Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.