BST-2 Rabbit Polyclonal Antibody

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008], disease:May play a role in B-cell activation in rheumatoid arthritis (RA) ., function:May be involved in the sorting of secreted proteins (By similarity) . May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation., induction:During B-cell activation (at protein level), or by interferon alpha as part of entiviral state cellular program., subunit:Homodimer., tissue specificity:Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highy expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level) .