RAP1 Rabbit Polyclonal Antibody

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010], function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways., miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Translated as Glu., similarity:Contains 1 BRCT domain., similarity:Contains 1 Myb-like domain., subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells., subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TRF2 (but not TRF1) with its C-terminus., tissue specificity:Ubiquitous. Highly expressed.

TERF2IP; DRIP5; RAP1; PP8000; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homol