MIP-1β Rabbit Polyclonal Antibody

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012], alternative products:CCL4L1 and CCL4L2 genes differ in their non-coding regions. Thus, alternative splicing events differ between the two genes, caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8., function:Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5., function:Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV) . The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta (3-69) is also a ligand for CCR1 and CCR2 isoform B., induction:By mitogens., online information:Macrophage inflammatory protein entry, polymorphism:The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome., PTM:N-terminal processed form MIP-1-beta (3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes., similarity:Belongs to the intercrine beta (chemokine CC) family., subunit:Homodimer and heterodimer of MIP-1-alpha (4-69) and MIP-1-beta (3-69) ., subunit:Interacts with CCR5., tissue specificity:Detected in B-cells.

CCL4; LAG1; MIP1B; SCYA4; C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta (1-69) ; Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2; ACT-2