Synaptotagmin XI Rabbit Polyclonal Antibody

Synaptotagmin 11 (SYT11) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010], cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains., function:May be involved in Ca (2+) -dependent exocytosis of secretory vesicles through Ca (2+) and phospholipid binding to the C2 domain or may serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis., PTM:Ubiquitinated and targeted to the proteasome complex for degradation., similarity:Belongs to the synaptotagmin family., similarity:Contains 2 C2 domains., subcellular location:In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients., subunit:Homodimer. Can also form heterodimers (By similarity) . Interacts with PARK2.