TCF-3 Rabbit Polyclonal Antibody

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010], domain:The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1., function:Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity) . Down-regulates NQO1, leading to increased mitomycin c resistance., similarity:Belongs to the TCF/LEF family., similarity:Contains 1 HMG box DNA-binding domain., subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex., tissue specificity:Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.