Cleaved-SUMO-2/3 (G93) Rabbit Polyclonal Antibody

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], function:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4., online information:SUMO protein entry, PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function., PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function., PTM:Polymeric chains can be formed through Lys-11 cross-linking., similarity:Belongs to the ubiquitin family. SUMO subfamily., similarity:Contains 1 ubiquitin-like domain., subcellular location:Nuclear bodies., subunit:Homotrimer (Potential) . Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1., subunit:Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins., tissue specificity:Broadly expressed., tissue specificity:Expressed predominantly in liver.