Laminin α-1 Rabbit Polyclonal Antibody

This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014], domain:Domains VI, IV and G are globular., domain:The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure., function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., similarity:Contains 1 laminin N-terminal domain., similarity:Contains 17 laminin EGF-like domains., similarity:Contains 2 laminin IV type A domains., similarity:Contains 5 laminin G-like domains., subcellular location:Major component., subunit:Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (EHS laminin) and laminin-3 (S-laminin) .