T2R43 Rabbit Polyclonal Antibody

TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]) . For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009], function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity) . Activated by the sulfonyl amide sweeteners saccharin and acesulfame K., miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli., similarity:Belongs to the G-protein coupled receptor T2R family., tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.