DNA pol α Rabbit Polyclonal Antibody

This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010], catalytic activity:Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1) ., function:Polymerase alpha in a complex with DNA primase is a replicative polymerase., miscellaneous:In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis., PTM:A 165 kDa form is probably produced by proteolytic cleavage at Lys-124., similarity:Belongs to the DNA polymerase type-B family., subunit:Interacts with SV40 Large T antigen; this interaction allows viral DNA replication.